Amber Tamblyn stars as Sarah Russell, a young woman who, upon learning she has leukemia, impulsively returns to her small hometown before facing her arduous treatment regimen. Home, viewers soon learn, is a place Sarah has avoided for some time. Her parents (Mary Elizabeth Mastrantonio, Tim DeKay), while concerned and supportive, seem tenuous and out of touch with their daughter. The Morrisseys, the Russells’ estranged neighbors, also appear strangely unnerved by Sarah’s sudden return, especially Lorraine (Jennifer Ehle), whose ongoing anxiety and headache problems escalate.